Modafinil Tablets

Modafinil is a wakefulness promoting agent used in Excessive sleepiness condition like Shift-Work Disorder, Narcolepsy and Obstructive Sleep Apnea. It works by inhibiting dopamine reuptake via blockade of the dopamine transporter (DAT) increasing extracellular dopamine level.

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  • Modafil Md 100

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  • Modacare 300

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  • Modacare 200 mg

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  • Modawake 200 mg

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  • Modvigil MD 200 mg

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  • Modalert 100mg

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  • Vilafinil 200 mg

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  • Modvigil 200mg

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  • Modavinil 200mg

    Rated 4.00 out of 5
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Key Features

About

 

Drug Class

Central Nervous System Stimulant

Components

Modafinil

Uses

For the treatment of Narcolepsy, Shift-Work Disorder and Obstructive Sleep Apnea.

Medications that contains Modafinil as an Active ingredient

How does Modafinil Work?

Modafil may enhances alertness, focus and wakefulness through modulation of several neurotransmitter system in brain.

  • Modafinil may leads to inhibition of dopamine reuptake via DAT, tends to increase extracellular dopamine level especially in the nucleus accumbens.
  • In tuberomammillary nucleus may activates histaminergic neurons that lead to arousal.
  • Orexin or Hypocretin signaling may get enhanced.
  • GABA release may get reduced and that tends to increase in glutamate release.
  • Unlike Amphetamines it does not activates the sympathetic nervous system and there’s low risk of side effects, hypertension, tachycardia, or euphoria.

Usage

  • It is used in the condition of Narcolepsy, Shift-work Disorder and Obstructive Sleep Apnea.
  • It may enhance the focus and alertness during night shift.
  • Attention Deficit Hyperactivity Disorder can be improved.
  • Cognitive enhancement, may used by students and professionals.

Dosage

  • The general starting dose in the condition of Narcolepsy, Obstructive Sleep Apnea Hypopnea Syndrome and Shift-work Disorder can be 100 mg.
  • The dosage may increase from 100 mg to 200 mg as per the individual requirement and tolerant rate.
  • Dosage may vary from individual to individual.

Side effects

  • Headache
  • Nausea
  • Anxiety
  • Insomnia
  • Dizziness
  • Dry Mouth
  • Palpitations
  • Diarrhea
  • Psychosis
  • Hallucinations

Interactions

  • Metabolism of modafinil is primarily mediated through the enzyme CYP3A4, and it has the ability to act as a moderate inducer of CYP3A4
  • Oral Contraceptives: Tends to decrease the effectiveness, other forms of contraception should be used.
  • CYP3A4 Inhibitors like ketoconazole, itraconazole, and ritonavir may increase modafinil plasma levels and increase the risk of toxicity.
  • CYP2C19 Substrates like diazepam, omeprazole, clopidogrel may interacts with modafinil adversely.

Precautions 

  • The one with medical history of psychosis, depression, cardiovascular disease, hepatic impairment may avoid such medications.
  • Pregnant and Breast feeding should also avoid such medications.
  • Alcohol and Caffeine intake with modafinil may interact adversely.

Conclusion 

Modafinil is a vigilance promoting drug that tends to treat various sleeping conditions like Narcolepsy, Obstructive sleep Apnea, and Shift Work Disorder by improving alertness. It works by inhibiting sleep-inducing factors such as adenosine, thereby inducing wakefulness, it is while generally well-tolerated it is required to consult a medical professional or health care provider to avoid any unwanted interactions and for better results.

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